Fig. 1 · Structure
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Fc 11a-2
NLRP3 Inflammasome Inhibitor
Fc 11a-2 is a benzimidazole compound that functions as a potent inhibitor of the NLRP3 inflammasome. It effectively reduces the activation of caspase-1, leading to decreased secretion of pro-inflammatory cytokines IL-1b and IL-18. This compound has demonstrated protective effects in model systems, including the prevention of Dextran sulfate sodium-induced murine experimental colitis, making it valuable for research in inflammation and related diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 960119-75-9 |
| Applications | NLRP3 Inflammasome Inhibitor |
| Formula | C16H16N2 |
| Molecular Weight | 236.31 |
| SMILES | CC1=CC=C2N(CC)C(C3=CC=CC=C3)=NC2=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.