Fenbendazole-d3 is a deuterium-labeled derivative of the anthelmintic agent Fenbendazole, targeting microtubules to destabilize their structure. This compound acts as a HIF-1α agonist, thereby activating the HIF-1α-mediated GLUT1 signaling pathway. Fenbendazole exhibits cell-cycle arrest and induces mitotic cell death, demonstrating significant antitumor activity in xenograft models using wild-type p53. Research applications include studies on cancer biology, parasitology, and mechanisms of cellular stress response.
Fenbendazole-d3 is a deuterium-labeled derivative of the anthelmintic agent Fenbendazole, targeting microtubules to destabilize their structure. This compound acts as a HIF-1α agonist, thereby activating the HIF-1α-mediated GLUT1 signaling pathway. Fenbendazole exhibits cell-cycle arrest and induces mitotic cell death, demonstrating significant antitumor activity in xenograft models using wild-type p53. Research applications include studies on cancer biology, parasitology, and mechanisms of cellular stress response.
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