Fig. 1 · Structure
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Fialuridine
Antiviral Agent
Fialuridine is a nucleoside analog that primarily acts as an antiviral agent targeting HSV-1 and HSV-2, exhibiting inhibition constants (Kis) of 0.14 μM and 0.95 μM, respectively. It also demonstrates significant anti-orthopoxvirus and anti-hepatitis B virus (HBV) activity. Fialuridine effectively inhibits duck HBV DNA replication, with IC50 values of 0.075 μM in human hepatoma cells and 156 μM in chicken liver cells, making it a valuable tool for research into viral replication and potential antiviral therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 69123-98-4 |
| Applications | Antiviral Agent |
| Formula | C9H10FIN2O5 |
| Molecular Weight | 372.09 |
| Synonyms | FIAU; DRG-0098; NSC 678514 |
| SMILES | O[C@H]1[C@H](F)[C@H](N2C(NC(C(I)=C2)=O)=O)O[C@@H]1CO |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.