- Chen CC, .et al. The Genomic Alterations of 5α-Reductases and Their Inhibitor Finasteride-s Effect in Bladder Cancer, Anticancer Res, 2017, Dec;37(12):6893-6898 PMID: 29187470
Biological Activity
Finasteride is a synthetic type II 5α-reductase inhibitor. This enzyme converts testosterone to dihydrotestosterone (DHT).
Targets
5-α reductase | ||||
10.2 nM(Ki) |
In vitro | DMSO | 67 mg/mL (179.85 mM) | |
Water | Insoluble | ||
Ethanol | 67 mg/mL (179.85 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 26.85 mL | 134.23 mL | 268.46 mL |
0.5 mM | 5.37 mL | 26.85 mL | 53.69 mL |
1 mM | 2.68 mL | 13.42 mL | 26.85 mL |
5 mM | 0.54 mL | 2.68 mL | 5.37 mL |
*The above data is based on the productmolecular weight 372.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10387 |
---|---|
CAS No. | 98319-26-7 |
Formula | C23H36N2O2 |
M. Wt | 372.5 |
Purity | >98% |
Synonyms | Proscar, Propecia |
SMILES | C[[email protected]]12CC[[email protected]]3[[email protected]]([[email protected]@H]1CC[[email protected]@H]2C(=O)NC(C)(C)C)CC[[email protected]@H]4[[email protected]@]3(C=CC(=O)N4)C |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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