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FK 973

DNA Crosslinking Inducer

FK 973 is a dihydrobenzoxazine compound that acts as a DNA crosslinking inducer. It selectively inhibits DNA synthesis and facilitates the formation of DNA cross-links via cytoplasmic activation. Demonstrating significant antitumor efficacy in multiple animal tumor models and human tumor xenografts, FK 973 exhibits relatively low myelosuppressive effects, particularly affecting neural tumor cells. This reagent is valuable for research focused on DNA-targeted antitumor strategies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inducer
CAS Number	114580-45-9
Applications	DNA Crosslinking Inducer
Formula	C₂₀H₂₁N₃O₉
Molecular Weight	447.40
SMILES	CC(O[C@]12[C@@H]3[C@H](C[N@@](C4=CC(C=O)=CC(OC(C)=O)=C4[C@@H]2COC(N)=O)O1)N3C(C)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.