FK888 is a highly selective dipeptide antagonist of the neurokinin-1 (NK1) receptor. It demonstrates a potent ability to displace [3H]-substance P binding, with a Ki value of 0.69 nM, making it an effective tool for studying NK1-related pathways. FK888 has been shown to inhibit substance P-induced airway edema in guinea pigs following both intravenous and oral administration, offering valuable insights for research in respiratory and inflammatory conditions.
FK888 is a highly selective dipeptide antagonist of the neurokinin-1 (NK1) receptor. It demonstrates a potent ability to displace [3H]-substance P binding, with a Ki value of 0.69 nM, making it an effective tool for studying NK1-related pathways. FK888 has been shown to inhibit substance P-induced airway edema in guinea pigs following both intravenous and oral administration, offering valuable insights for research in respiratory and inflammatory conditions.
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