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$0.00 - Zhiyuan Zhao, .et al. CDK9 and SPT5 proteins are specifically required for expression of herpes simplex virus 1 replication-dependent late genes, J Biol Chem, 2017, Sep 15; 292(37): 15489-15500 PMID: 28743741
- Sami Kukkonen, .et al. HIV-1 Tat second exon limits the extent of Tat-mediated modulation of interferon-stimulated genes in antigen presenting cells, Retrovirology., 2014, 11: 30. PMID: 24742347
Biological Activity
Flavopiridol (Alvocidib) is a cyclin-dependent kinase inhibitor under clinical development for the treatment of chronic lymphocytic leukemia.
Targets
| CDK1 | CDK2 | CDK4 | CDK6 | CDK7 |
| 40 nM | 40 nM | 40 nM | 40 nM | 300 nM |
| In vitro (25°C) | DMSO | 14 mg/mL (34.83 mM) | |
| Water | 7 mg/mL (17.41 mM) | ||
| Ethanol | Insoluble | ||
| In vivo | 5% DMSO+30% PEG 300+ddH2O | 2.3 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.89 mL | 124.44 mL | 248.88 mL |
| 0.5 mM | 4.98 mL | 24.89 mL | 49.78 mL |
| 1 mM | 2.49 mL | 12.44 mL | 24.89 mL |
| 5 mM | 0.5 mL | 2.49 mL | 4.98 mL |
*The above data is based on the productmolecular weight 401.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10390 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 146426-40-6 |
| Formula | C21H20ClNO5 |
| M. Wt | 401.8 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | HMR-1275, L868275 |
| SMILES | CN1CC[[email protected]@H]([[email protected]@H](C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
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