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Flavopiridol (Alvocidib)

Flavopiridol (Alvocidib)

Name: Flavopiridol (Alvocidib)
Brand: Adooq Bioscience
SKU: A10390
Rating: 100 (3 reviews)

Catalog No.: A10390

CDK inhibitor

Product Citations (3)

Flavopiridol (Alvocidib) Chemical Structure

CAS NO. 146426-40-6

Flavopiridol (Alvocidib) is a cyclin-dependent kinase inhibitor under clinical development for the treatment of chronic lymphocytic leukemia.

Availability: In stock

Package	Price	Qty
5 mg	$40.00
10 mg	$70.00
25 mg	$120.00
50 mg	$200.00
10mM * 1mL in DMSO	$91.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq Flavopiridol (Alvocidib)

Reiko Watanabe, .et al. Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration, J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967
Zhiyuan Zhao, .et al. CDK9 and SPT5 proteins are specifically required for expression of herpes simplex virus 1 replication-dependent late genes, J Biol Chem, 2017, Sep 15; 292(37): 15489-15500 PMID: 28743741
Sami Kukkonen, .et al. HIV-1 Tat second exon limits the extent of Tat-mediated modulation of interferon-stimulated genes in antigen presenting cells, Retrovirology., 2014, 11: 30. PMID: 24742347

Biological Activity

Flavopiridol (Alvocidib) is a cyclin-dependent kinase inhibitor under clinical development for the treatment of chronic lymphocytic leukemia.

Targets

CDK1	CDK2	CDK4	CDK6	CDK7
40 nM	40 nM	40 nM	40 nM	300 nM

Solubility *

In vitro (25°C)	DMSO	14 mg/mL (34.83 mM)
	Water	Insoluble
	Ethanol	7 mg/mL (17.41 mM)
In vivo	5% DMSO+30% PEG 300+ddH2O	2.3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.89 mL	124.44 mL	248.88 mL
0.5 mM	4.98 mL	24.89 mL	49.78 mL
1 mM	2.49 mL	12.44 mL	24.89 mL
5 mM	0.5 mL	2.49 mL	4.98 mL

*The above data is based on the productmolecular weight 401.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10390
Actions	Inhibitor
CAS No.	146426-40-6
Formula	C21H20ClNO5
M. Wt	401.8
Purity	>98%
Synonyms	HMR-1275, L868275
SMILES	CN1CC[[email protected]@H]([[email protected]@H](C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.