Flavopiridol (Alvocidib)

Catalog No.: A10390

CDK inhibitor

Flavopiridol (Alvocidib)

Flavopiridol (Alvocidib) Chemical Structure

CAS NO. 146426-40-6

Flavopiridol (Alvocidib) is a cyclin-dependent kinase inhibitor under clinical development for the treatment of chronic lymphocytic leukemia.

Availability: In stock

Package Price Qty
5 mg
$40.00
10 mg
$70.00
25 mg
$120.00
50 mg
$200.00
10mM * 1mL in DMSO
$91.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Zhiyuan Zhao, .et al. CDK9 and SPT5 proteins are specifically required for expression of herpes simplex virus 1 replication-dependent late genes, J Biol Chem, 2017, Sep 15; 292(37): 15489-15500 PMID: 28743741
  • Sami Kukkonen, .et al. HIV-1 Tat second exon limits the extent of Tat-mediated modulation of interferon-stimulated genes in antigen presenting cells, Retrovirology., 2014, 11: 30. PMID: 24742347

Biological Activity

Flavopiridol (Alvocidib) is a cyclin-dependent kinase inhibitor under clinical development for the treatment of chronic lymphocytic leukemia.
Targets
CDK1 CDK2 CDK4 CDK6 CDK7
40 nM40 nM40 nM40 nM300 nM
In vitro (25°C) DMSO 14 mg/mL (34.83 mM)
Water 7 mg/mL (17.41 mM)
Ethanol Insoluble
In vivo 5% DMSO+30% PEG 300+ddH2O 2.3 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.89 mL 124.44 mL 248.88 mL
0.5 mM 4.98 mL 24.89 mL 49.78 mL
1 mM 2.49 mL 12.44 mL 24.89 mL
5 mM 0.5 mL 2.49 mL 4.98 mL

*The above data is based on the productmolecular weight 401.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10390
Actions Inhibitor
CAS No. 146426-40-6
Formula C21H20ClNO5
M. Wt 401.8
Solubility DMSO
Purity >98%
Synonyms HMR-1275, L868275
SMILES CN1CC[[email protected]@H]([[email protected]@H](C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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