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Flavopiridol (Alvocidib) is a cyclin-dependent kinase inhibitor under clinical development for the treatment of chronic lymphocytic leukemia.
Targets
| CDK1 | CDK2 | CDK4 | CDK6 | CDK7 |
| 40 nM | 40 nM | 40 nM | 40 nM | 300 nM |
| In vitro (25°C) | DMSO | 88 mg/mL (200.77 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.89 mL | 124.44 mL | 248.88 mL |
| 0.5 mM | 4.98 mL | 24.89 mL | 49.78 mL |
| 1 mM | 2.49 mL | 12.44 mL | 24.89 mL |
| 5 mM | 0.5 mL | 2.49 mL | 4.98 mL |
*The above data is based on the productmolecular weight 401.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10390 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 401.8 |
| Formula | C21H20ClNO5 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 146426-40-6 |
| Synonyms | HMR-1275, L868275 |
| SMILES | CN1CC[[email protected]@H]([[email protected]@H](C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O |
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