Flavopiridol (Alvocidib)

Catalog No.: A10390

CDK inhibitor

Flavopiridol (Alvocidib) Chemical Structure

CAS NO. 146426-40-6

Flavopiridol (Alvocidib) is a cyclin-dependent kinase inhibitor under clinical development for the treatment of chronic lymphocytic leukemia.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $40.00

Special Price $32.00

10 mg

Regular Price: $70.00

Special Price $56.00

25 mg

Regular Price: $120.00

Special Price $96.00

50 mg

Regular Price: $200.00

Special Price $160.00

10mM * 1mL in DMSO
$91.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Flavopiridol (Alvocidib) is a cyclin-dependent kinase inhibitor under clinical development for the treatment of chronic lymphocytic leukemia.
Targets
CDK1 CDK2 CDK4 CDK6 CDK7
40 nM40 nM40 nM40 nM300 nM
In vitro (25°C) DMSO 88 mg/mL (200.77 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.89 mL 124.44 mL 248.88 mL
0.5 mM 4.98 mL 24.89 mL 49.78 mL
1 mM 2.49 mL 12.44 mL 24.89 mL
5 mM 0.5 mL 2.49 mL 4.98 mL

*The above data is based on the productmolecular weight 401.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10390
Actions Inhibitor
M. Wt 401.8
Formula C21H20ClNO5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 146426-40-6
Synonyms HMR-1275, L868275
SMILES CN1CC[[email protected]@H]([[email protected]@H](C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O

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