Customer Appreciation Sale.
15% off with promo code "APPRECIATION2023" on check out or purchase order
- Reiko Watanabe, .et al. Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration, J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967
- Zhiyuan Zhao, .et al. CDK9 and SPT5 proteins are specifically required for expression of herpes simplex virus 1 replication-dependent late genes, J Biol Chem, 2017, Sep 15; 292(37): 15489-15500 PMID: 28743741
- Sami Kukkonen, .et al. HIV-1 Tat second exon limits the extent of Tat-mediated modulation of interferon-stimulated genes in antigen presenting cells, Retrovirology., 2014, 11: 30. PMID: 24742347
Biological Activity
Flavopiridol (Alvocidib) is a cyclin-dependent kinase inhibitor under clinical development for the treatment of chronic lymphocytic leukemia.
Targets
CDK1 | CDK2 | CDK4 | CDK6 | CDK7 |
40 nM | 40 nM | 40 nM | 40 nM | 300 nM |
In vitro (25°C) | DMSO | 14 mg/mL (34.83 mM) | |
Water | Insoluble | ||
Ethanol | 7 mg/mL (17.41 mM) | ||
In vivo | 5% DMSO+30% PEG 300+ddH2O | 2.3 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 24.89 mL | 124.44 mL | 248.88 mL |
0.5 mM | 4.98 mL | 24.89 mL | 49.78 mL |
1 mM | 2.49 mL | 12.44 mL | 24.89 mL |
5 mM | 0.5 mL | 2.49 mL | 4.98 mL |
*The above data is based on the productmolecular weight 401.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10390 |
---|---|
Actions | Inhibitor |
CAS No. | 146426-40-6 |
Formula | C21H20ClNO5 |
M. Wt | 401.8 |
Purity | >98% |
Synonyms | HMR-1275, L868275 |
SMILES | CN1CC[[email protected]@H]([[email protected]@H](C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O |
Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
Roscovitine (Seliciclib)
Roscovitine (Seliciclib) is a CDK inhibitor that preferentially inhibit multiple enzyme targets including CDK2, CDK7 and CDK9.
Purvalanol B
Purvalanol B is a cyclin-dependent kinase inhibitor. IC50 values are 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cycl…
AG-024322
AG-24322 is a second generation CDK inhibitor. AG-024322 is a potent inhibitor of CDK1, CDK2, and CDK4 that produces cell-cycle arrest and a…
PHA-848125 (Milciclib)
PHA-848125 (Milciclib) is an orally bioavailable inhibitor of CDKs and TRKA with potential antineoplastic activity.
TG003
TG003 is a potent, specific, reversible, and ATP competitive inhibitor of Cdc2 like kinase(Clk).-
PD 0332991 HCl (Palbociclib)
PD 0332991 HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activit…
AT7519 HCl
AT7519 is an inhibitor of multiple cyclin-dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhib…
NVP-LCQ195
NVP-LCQ195 is a small molecule heterocyclic inhibitor of CDK1, CDK2, CDK3 and CDK5 with IC50 of 1-42 nM.
Keywords:buy Flavopiridol (Alvocidib) | Flavopiridol (Alvocidib) Supplier | purchase | cost | manufacturer | order | distributor | buy 146426-40-6| 146426-40-6 Supplier | purchase 146426-40-6 | 146426-40-6 cost | 146426-40-6 manufacturer | order 146426-40-6 | 146426-40-6 distributor