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Flavopiridol HCl

Flavopiridol HCl

Name: Flavopiridol HCl
Brand: Adooq Bioscience
SKU: A11045
Rating: 100 (268 reviews)

Catalog No.: A11045

CDK inhibitor

Flavopiridol HCl Chemical Structure

CAS NO. 131740-09-5

Flavopiridol HCl is an inhibitor of cyclin-dependent kinases. The (-)-cis form induces apoptosis in particular tumor cells.

Availability: In stock

Package	Price	Qty
10 mg	$60.00
25 mg	$120.00
50 mg	$200.00
100 mg	$350.00
10mM * 1mL in DMSO	$85.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Biological Activity

Flavopiridol HCl is an inhibitor of cyclin-dependent kinases. The (-)-cis form induces apoptosis in particular tumor cells.

Targets

CDK1 (Cell-free assay)	CDK2 (Cell-free assay)	CDK4 (Cell-free assay)	CDK6 (Cell-free assay)	CDK7 (Cell-free assay)
40 nM	40 nM	40 nM	40 nM	300 nM

Solubility *

In vitro (25°C)	DMSO	78 mg/mL (177.96 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.82 mL	114.08 mL	228.15 mL
0.5 mM	4.56 mL	22.82 mL	45.63 mL
1 mM	2.28 mL	11.41 mL	22.82 mL
5 mM	0.46 mL	2.28 mL	4.56 mL

*The above data is based on the productmolecular weight 438.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A11045
Actions	Inhibitor
CAS No.	131740-09-5
Formula	C21H20ClNO5.HCl
M. Wt	438.3
Purity	>98%
SMILES	CN1CC[[email protected]@H]([[email protected]@H](C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O.Cl
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.