Flavopiridol HCl

Catalog No.: A11045

CDK inhibitor

Flavopiridol HCl Chemical Structure

CAS NO. 131740-09-5

Flavopiridol HCl is an inhibitor of cyclin-dependent kinases. The (-)-cis form induces apoptosis in particular tumor cells.

Availability: In stock

Package Price Qty
10 mg
$60.00
25 mg
$120.00
50 mg
$200.00
100 mg
$350.00
10mM * 1mL in DMSO
$85.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Flavopiridol HCl is an inhibitor of cyclin-dependent kinases. The (-)-cis form induces apoptosis in particular tumor cells.
Targets
CDK1 (Cell-free assay) CDK2 (Cell-free assay) CDK4 (Cell-free assay) CDK6 (Cell-free assay) CDK7 (Cell-free assay)
40 nM40 nM40 nM40 nM300 nM
In vitro (25°C) DMSO 88 mg/mL (200.77 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.82 mL 114.08 mL 228.15 mL
0.5 mM 4.56 mL 22.82 mL 45.63 mL
1 mM 2.28 mL 11.41 mL 22.82 mL
5 mM 0.46 mL 2.28 mL 4.56 mL

*The above data is based on the productmolecular weight 438.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11045
Actions Inhibitor
M. Wt 438.3
Formula C21H20ClNO5.HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 131740-09-5
Synonyms N/A
SMILES CN1CC[[email protected]@H]([[email protected]@H](C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O.Cl

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