Flavopiridol HCl

Catalog No.: A11045

CDK inhibitor

Flavopiridol HCl

Flavopiridol HCl Chemical Structure

CAS NO. 131740-09-5

Flavopiridol HCl is an inhibitor of cyclin-dependent kinases. The (-)-cis form induces apoptosis in particular tumor cells.

Availability: In stock

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10 mg
25 mg
50 mg
100 mg
10mM * 1mL in DMSO
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Biological Activity

Flavopiridol HCl is an inhibitor of cyclin-dependent kinases. The (-)-cis form induces apoptosis in particular tumor cells.
CDK1 (Cell-free assay) CDK2 (Cell-free assay) CDK4 (Cell-free assay) CDK6 (Cell-free assay) CDK7 (Cell-free assay)
40 nM40 nM40 nM40 nM300 nM
In vitro (25°C) DMSO 78 mg/mL (177.96 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+30% PEG 300+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.82 mL 114.08 mL 228.15 mL
0.5 mM 4.56 mL 22.82 mL 45.63 mL
1 mM 2.28 mL 11.41 mL 22.82 mL
5 mM 0.46 mL 2.28 mL 4.56 mL

*The above data is based on the productmolecular weight 438.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11045
Actions Inhibitor
CAS No. 131740-09-5
Formula C21H20ClNO5.HCl
M. Wt 438.3
Purity >98%
SMILES CN1CC[[email protected]@H]([[email protected]@H](C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O.Cl

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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