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Florbenazine

Biochemical Assay Reagent

Florbenazine is a diagnostic imaging agent that selectively targets the vesicular monoamine transporter 2 (VMAT2) in the central nervous system. The fluorine-18 labeled derivative is utilized in positron emission tomography (PET) scanning to assess neuromodulatory functions. Research has demonstrated a significant biodistribution profile in mice, with a high striatum-to-cerebellum ratio, supporting its application in the diagnostic investigation of neurodegenerative disorders, such as dementia with Lewy bodies and Parkinson’s disease.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	937245-42-6
Applications	Biochemical Assay Reagent
Formula	C₂₁H₃₂FNO₃
Molecular Weight	365.48
Synonyms	AV-133
SMILES	COC1=C(OCCCF)C=C2CCN(C[C@H]([C@@H](C3)O)CC(C)C)[C@@]3([H])C2=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.