Fig. 1 · Structure
Documents & Downloads
FM26
Cat. No.
A77583
CAS
2407981-35-3
RORγt Inverse Agonist
FM26 is a potent allosteric inverse agonist of the retinoic acid receptor-related orphan receptor γt (RORγt), exhibiting an IC50 of 264 nM. This compound effectively downregulates IL-17a mRNA expression in EL4 cells, making it a valuable tool for studying Th17 cell differentiation and related immunological responses. FM26 is suitable for research applications focusing on autoimmune diseases and inflammation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inverse Agonist |
| CAS Number | 2407981-35-3 |
| Applications | RORγt Inverse Agonist |
| Formula | C22H15ClF3N3O3 |
| Molecular Weight | 461.82 |
| SMILES | O=C(O)C1=CC=C(NCC2=C(C3=CNC=C3)ON=C2C4=C(C(F)(F)F)C=CC=C4Cl)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.