FMS586 free base is a selective antagonist of the neuropeptide Y Y5 receptor, exhibiting oral bioactivity. It effectively inhibits the hPP-induced increase in adrenocorticotropic hormone (ACTH) and cortisol levels, and reverses the upregulation of corticotropin-releasing hormone (CRF) and vasopressin (AVP) mRNA expression following central administration of hPP. This compound offers valuable insights into the role of Y5 receptors in activating the hypothalamic-pituitary-adrenal (HPA) axis, making it a significant tool for studying neuroendocrine regulation.
FMS586 free base is a selective antagonist of the neuropeptide Y Y5 receptor, exhibiting oral bioactivity. It effectively inhibits the hPP-induced increase in adrenocorticotropic hormone (ACTH) and cortisol levels, and reverses the upregulation of corticotropin-releasing hormone (CRF) and vasopressin (AVP) mRNA expression following central administration of hPP. This compound offers valuable insights into the role of Y5 receptors in activating the hypothalamic-pituitary-adrenal (HPA) axis, making it a significant tool for studying neuroendocrine regulation.
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