Fig. 1 · Structure

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Fosmidomycin

Antimalarial Agent

Fosmidomycin is an orally active antibiotic that targets 1-deoxy-D-xylulose 5-phosphate reductoisomerase, thereby demonstrating notable antimalarial activity. It effectively inhibits various Plasmodium falciparum strains, including 3D7, HB3, Dd2, and A2, with IC50 values ranging from 71 to 170 ng/mL. Additionally, Fosmidomycin has shown synergistic effects when combined with Clindamycin and has been proven to alleviate malaria symptoms in mouse models, making it a valuable tool in malaria research.

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Specifications

Manufacturer Adooq Bioscience
CAS Number 66508-53-0
Applications Antimalarial Agent
Formula C4H10NO5P
Molecular Weight 183.10
SMILES
OP(O)(CCCN(C=O)O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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