Fosnetupitant chloride monohydrochloride is an NK1 receptor antagonist designed to inhibit neurokinin-1 signaling. It demonstrates high affinity for the human NK1 receptor with a pKi value of 9.5 and exhibits moderate activity at the NK3 receptor with a pKi value of 6.1. This compound serves as a methylene phosphate prodrug of Netupitant, making it a valuable tool for research in the fields of oncology and pain management, particularly for evaluating antiemetic properties and exploring neurokinin-related pathways.
Fosnetupitant chloride monohydrochloride is an NK1 receptor antagonist designed to inhibit neurokinin-1 signaling. It demonstrates high affinity for the human NK1 receptor with a pKi value of 9.5 and exhibits moderate activity at the NK3 receptor with a pKi value of 6.1. This compound serves as a methylene phosphate prodrug of Netupitant, making it a valuable tool for research in the fields of oncology and pain management, particularly for evaluating antiemetic properties and exploring neurokinin-related pathways.
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