Fig. 1 · Structure
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Fosnetupitant chloride monohydrochloride
NK1 Antagonist
Fosnetupitant chloride monohydrochloride is an NK1 receptor antagonist designed to inhibit neurokinin-1 signaling. It demonstrates high affinity for the human NK1 receptor with a pKi value of 9.5 and exhibits moderate activity at the NK3 receptor with a pKi value of 6.1. This compound serves as a methylene phosphate prodrug of Netupitant, making it a valuable tool for research in the fields of oncology and pain management, particularly for evaluating antiemetic properties and exploring neurokinin-related pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1643757-72-5 |
| Applications | NK1 Antagonist |
| Formula | C31H37Cl2F6N4O5P |
| Molecular Weight | 761.52 |
| Synonyms | Pronetupitant chloride monohydrochloride |
| SMILES | O=C(C(C)(C)C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)N(C)C2=CN=C(N3CC[N+](COP(O)(O)=O)(CC3)C)C=C2C4=C(C)C=CC=C4.[H]Cl.[Cl-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.