Fig. 1 · Structure
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Fosnetupitant
Prodrug Of Netupitant
Fosnetupitant is a prodrug of Netupitant, functioning primarily as a selective antagonist of the human neurokinin-1 (NK1) receptor. With a pKi of 9.5, it offers significant inhibitory activity, making it a valuable tool in research focused on neurokinin signaling pathways. Fosnetupitant is utilized in studies related to pain management, nausea, and the effects of substance P in various biological systems.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1703748-89-3 |
| Applications | Prodrug Of Netupitant |
| Formula | C31H35F6N4O5P |
| Molecular Weight | 688.60 |
| Synonyms | Pronetupitant |
| SMILES | O=P(OC[N+]1(C)CCN(C2=NC=C(N(C)C(C(C)(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C)=O)C(C4=CC=CC=C4C)=C2)CC1)([O-])O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.