Fig. 1 · Structure
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FOXO1-IN-3
FOXO1 Inhibitor
FOXO1-IN-3 is a selective inhibitor of FOXO1, a crucial transcription factor involved in glucose metabolism. This compound has demonstrated efficacy in reducing hepatic glucose production in murine models. Additionally, FOXO1-IN-3 enhances insulin sensitivity and improves glucose control in db/db mice, while not contributing to weight gain, making it a valuable tool for research on metabolic disorders and insulin resistance.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2451093-95-9 |
| Applications | FOXO1 Inhibitor |
| Formula | C22H23N7O |
| Molecular Weight | 401.46 |
| SMILES | O=C(C1=CC=C(N2CCN(CC2)C)C=C1)NC3=CC(C4=NC5=C(N4)C=CC=C5)=NN3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.