Fig. 1 · Structure
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FP802 dihydrochloride
TwinF Interface Inhibitor
FP802 dihydrochloride is a potent TwinF interface inhibitor that effectively disrupts the NMDAR/TRPM4 death complex. This compound demonstrates significant neuroprotective properties in the 5xFAD mouse model of Alzheimer's disease, mitigating cognitive decline, preserving neuronal integrity, and reducing amyloid-β plaque accumulation. Additionally, FP802 dihydrochloride prevents motor neuron loss, lowers serum neurofilament light chain (NfL) levels, enhances motor performance, and prolongs lifespan in mouse models of amyotrophic lateral sclerosis. This reagent is suitable for research related to Alzheimer's disease and amyotrophic lateral sclerosis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2490401-57-3 |
| Applications | TwinF Interface Inhibitor |
| Formula | C11H19Cl3N2 |
| Molecular Weight | 285.64 |
| SMILES | CCN(CC1=CC(Cl)=CC=C1)CCN.Cl.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.