Fig. 1 · Structure
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FP802
TwinF Interface Inhibitor
FP802 is a potent TwinF interface inhibitor that disrupts the NMDAR/TRPM4 death complex, providing promising neuroprotective effects. In the 5xFAD mouse model of Alzheimer’s disease, FP802 prevents cognitive decline, preserves neuronal integrity, reduces amyloid-β plaque accumulation, and alleviates mitochondrial dysfunction. Additionally, it mitigates motor neuron loss, lowers serum neurofilament light chain (NfL) levels, enhances motor performance, and extends lifespan in a mouse model of amyotrophic lateral sclerosis (ALS). FP802 is suitable for research applications related to Alzheimer's disease and ALS.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 61694-81-3 |
| Applications | TwinF Interface Inhibitor |
| Formula | C11H17ClN2 |
| Molecular Weight | 212.72 |
| SMILES | CCN(CC1=CC(Cl)=CC=C1)CCN |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.