Fig. 1 · Structure
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FR173657
Bradykinin B2 Receptor Antagonist
FR173657 is a potent orally active antagonist of the bradykinin B2 receptor, exhibiting IC50 values of 0.56, 1.5, and 2.9 nM for pig, rat, and human receptors, respectively. This compound effectively inhibits bradykinin-induced bronchoconstriction in guinea pigs with an ED50 of 0.075 mg/kg and demonstrates the ability to reduce carrageenan-induced paw edema in mice at an ED50 of 6.8 mg/kg. FR173657 is valuable for research into inflammatory diseases and related physiological responses.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 167838-64-4 |
| Applications | Bradykinin B2 Receptor Antagonist |
| Formula | C30H27Cl2N5O4 |
| Molecular Weight | 592.47 |
| Synonyms | FK-3657 |
| SMILES | O=C(NCC(N(C1=CC=C(Cl)C(COC2=C3N=C(C)C=CC3=CC=C2)=C1Cl)C)=O)/C=C/C4=CC=C(NC(C)=O)N=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.