Fig. 1 · Structure
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FR191413
Bradykinin B2 Receptor Agonist
FR191413 is a selective bradykinin B2 receptor agonist that activates bradykinin-mediated pathways including vasodilation and organ protection through the stimulation of prostaglandin E2 production in WI-38 cells. It competitively binds to [3H]-BK in guinea pig ileum membranes and CHO cells transfected with the human B2 receptor, exhibiting IC50 values of 20.0 nM and 2.60 nM, respectively. This compound is useful in researching cardiovascular conditions such as hypertension, myocardial hypertrophy, myocardial infarction, arrhythmias, and diabetic nephropathy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 194928-55-7 |
| Applications | Bradykinin B2 Receptor Agonist |
| Formula | C34H31Cl2N7O5 |
| Molecular Weight | 688.57 |
| SMILES | O(CC1=C(Cl)C(N(C(CNC(/C=C/C=2C=CC(NC(C)=O)=NC2)=O)=O)C)=CC=C1Cl)C3=C4C(N(CC5=CC=CC=N5)C(OC)=N4)=CC=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.