Fig. 1 · Structure
Documents & Downloads
FTI 276 TFA
Farnesyl Transferase Inhibitor
FTI 276 TFA is a potent inhibitor of protein farnesyl transferase (PFT) with reported IC50 values of 0.9 nM for Plasmodium falciparum and 0.5 nM for human enzymes. This compound demonstrates significant biological activity in the modulation of protein farnesylation, a crucial process in cell signaling and tumorigenesis. FTI 276 TFA is primarily used in research applications focusing on cancer biology and inflammation, contributing to the understanding of farnesyl transferase's role in various disease states.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1217471-51-6 |
| Applications | Farnesyl Transferase Inhibitor |
| Formula | C23H28F3N3O5S2 |
| Molecular Weight | 547.61 |
| SMILES | O=C(O)[C@@H](NC(C1=CC=C(NC[C@@H](N)CS)C=C1C2=CC=CC=C2)=O)CCSC.O=C(O)C(F)(F)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.