Furosemide-d5 is a deuterium-labeled derivative of furosemide, primarily targeting the Na+/K+/2Cl- cotransporters, NKCC1 and NKCC2. This compound acts as a potent loop diuretic, exhibiting significant biological activity in the management of conditions such as congestive heart failure, hypertension, and edema. Additionally, furosemide-d5 can function as a GABAA receptor antagonist, demonstrating enhanced selectivity for α6-containing receptors. It serves as a valuable tool for biochemical research and pharmacokinetic studies involving furosemide.
Furosemide-d5 is a deuterium-labeled derivative of furosemide, primarily targeting the Na+/K+/2Cl- cotransporters, NKCC1 and NKCC2. This compound acts as a potent loop diuretic, exhibiting significant biological activity in the management of conditions such as congestive heart failure, hypertension, and edema. Additionally, furosemide-d5 can function as a GABAA receptor antagonist, demonstrating enhanced selectivity for α6-containing receptors. It serves as a valuable tool for biochemical research and pharmacokinetic studies involving furosemide.
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