Vismodegib-d7 is a deuterium-labeled form of Vismodegib, a potent inhibitor of the hedgehog signaling pathway, with an IC50 of 3 nM. In addition to its primary action, Vismodegib also demonstrates inhibition of P-glycoprotein (P-gp) and ABCG2, with IC50 values of 3.0 μM and 1.4 μM, respectively. This stable isotope variant is beneficial for pharmacokinetic studies and metabolic profiling in research applications related to cancer therapeutics and signaling pathways.
Vismodegib-d7 is a deuterium-labeled form of Vismodegib, a potent inhibitor of the hedgehog signaling pathway, with an IC50 of 3 nM. In addition to its primary action, Vismodegib also demonstrates inhibition of P-glycoprotein (P-gp) and ABCG2, with IC50 values of 3.0 μM and 1.4 μM, respectively. This stable isotope variant is beneficial for pharmacokinetic studies and metabolic profiling in research applications related to cancer therapeutics and signaling pathways.
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