FXIa/Plasma kallikrein-IN-1

Catalog No.: A64982
FXIa/Kallikrein Inhibitor
FXIa/Plasma kallikrein-IN-1 is a potent inhibitor of coagulation factor XIa (FXIa) and plasma kallikrein, exhibiting Ki values of 187.70 nM and 151.6 nM, respectively. This compound serves as a valuable tool for investigating thromboembolic diseases and related disorders. Its selective inhibition of these targets can facilitate the exploration of pathological mechanisms and the development of therapeutic strategies for coagulopathies.
Grouped product items
Size Price Stock Qty
25mg
$1,275.00
In stock
50mg
$1,625.00
In stock
100mg
$2,000.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionFXIa/Plasma kallikrein-IN-1 is a potent inhibitor of coagulation factor XIa (FXIa) and plasma kallikrein, exhibiting Ki values of 187.70 nM and 151.6 nM, respectively. This compound serves as a valuable tool for investigating thromboembolic diseases and related disorders. Its selective inhibition of these targets can facilitate the exploration of pathological mechanisms and the development of therapeutic strategies for coagulopathies.
Product Information
Catalog NumA64982
FormulaC31H29ClF2N4O4
Molecular Weight595.04
CAS Number1551460-43-5
SMILESCOC(NC1=CC=C(C2=CC([C@@H](CCC[C@H](C3=O)C)N(CCC(C4=C(C=CC(Cl)=C4F)F)=C5)C5=O)=NC=C2)C(N3)=C1)=O
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