γ-Amanitin is a potent ADC cytotoxin derived from the Amanita mushroom, specifically targeting RNA polymerase II to inhibit mRNA synthesis. This compound exhibits high toxicity across various cell types, making it a valuable tool in cancer research and therapeutic applications. γ-Amanitin competes effectively with monoclonal antibodies, displaying an IC50 value of 163.1 ng/mL. Its ability to disrupt transcriptional processes positions it as a key reagent in studies focused on gene expression and cellular response mechanisms.
γ-Amanitin is a potent ADC cytotoxin derived from the Amanita mushroom, specifically targeting RNA polymerase II to inhibit mRNA synthesis. This compound exhibits high toxicity across various cell types, making it a valuable tool in cancer research and therapeutic applications. γ-Amanitin competes effectively with monoclonal antibodies, displaying an IC50 value of 163.1 ng/mL. Its ability to disrupt transcriptional processes positions it as a key reagent in studies focused on gene expression and cellular response mechanisms.
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