Fig. 1 · Structure
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GAK inhibitor 49 hydrochloride
GAK Inhibitor
GAK Inhibitor 49 Hydrochloride is a potent, ATP-competitive inhibitor that selectively targets cyclin G associated kinase (GAK) with a Ki value of 0.54 nM, demonstrating significant inhibitory effects on cellular activity with an IC50 of 56 nM. Additionally, this compound exhibits binding affinity for RIPK2, making it a valuable tool for research applications aimed at understanding GAK's role in cellular processes and its potential implications in various diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2930378-91-7 |
| Applications | GAK Inhibitor |
| Formula | C20H23ClN2O5 |
| Molecular Weight | 406.86 |
| SMILES | COC1=C(OC)C(OC)=CC(NC2=CC=NC3=CC(OC)=C(OC)C=C23)=C1.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.