Fig. 1 · Structure
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GAK inhibitor 49
GAK Inhibitor
GAK Inhibitor 49 is a highly selective cyclin G associated kinase (GAK) inhibitor that operates through an ATP-competitive mechanism, exhibiting a Ki value of 0.54 nM and a cell IC50 of 56 nM. Additionally, it demonstrates binding affinity to receptor-interacting protein kinase 2 (RIPK2). This compound is valuable for research into GAK-related signaling pathways and potential therapeutic interventions in various diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 319492-82-5 |
| Applications | GAK Inhibitor |
| Formula | C20H22N2O5 |
| Molecular Weight | 370.40 |
| SMILES | COC1=C(OC)C(OC)=CC(NC2=CC=NC3=CC(OC)=C(OC)C=C23)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.