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Garcinol

Name: Garcinol
Brand: Adooq Bioscience
SKU: A12814
Availability: InStock

Cat. No. A12814 CAS 78824-30-3

HAT inhibitor

Garcinol is a polyisoprenylated benzophenone derivative isolated from Garcinia indica. It is a potent inhibitor of histone acetyltransferases (HATs) p300 (IC50=7μM) and PCAF (IC50=5μM) both in vitro and in vivo.

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Biological Activity

Target & Activity

Target	Activity	Value
AChE
BChE
GCN5/PCAF
Human Endogenous Metabolite

Cellular Effect

Cell Line	Activity	Value	Description	Reference
Sf21	IC50	5 μM	Inhibition of FLAG epitope-tagged recombinant human PCAF expressed in baculovirus infected insect Sf21 cells using [3H]acetyl-CoA as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by liquid scintillation counting	10.1039/C1MD00199J
Sf21	IC50	7 μM	Inhibition of His6-tagged recombinant full length p300 (unknown origin) expressed in baculovirus infected insect Sf21 cells using [3H]acetyl-CoA as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by liquid scintill	10.1039/C1MD00199J

Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	78824-30-3
Applications	HAT inhibitor
Formula	C₃₈H₅₀O₆
Molecular Weight	602.8
Synonyms	camboginol
SMILES	CC(=CC[C@@H]1C[C@@]2(C(=O)/C(=C(\C3=CC(=C(C=C3)O)O)/O)/C(=O)[C@@](C2=O)(C1(C)C)CC=C(C)C)C[C@H](CC=C(C)C)C(=C)C)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.