GDC-0810 (Brilanestrant)

Catalog No.: A15958

Estrogen receptor degrader

GDC-0810 (Brilanestrant)

GDC-0810 (Brilanestrant) Chemical Structure

CAS NO. 1365888-06-7

Brilanestrant (GDC-0810, ARN-810) is a potent ER-α binder (ER-α, IC50 = 6.1 nM; ER-β, IC50 = 8.8 nM), a full transcriptional antagonist with no agonism and displays good potency and efficacy in ER-α degradation (EC50 = 0.7 nM) and MCF-7 breast cancer cell viability (IC50 = 2.5 nM) assays with good selectivity over other nuclear hormone receptors.

Availability: In stock

Package Price Qty
5 mg
$130.00
10 mg
$195.00
25 mg
$380.00
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Biological Activity

Brilanestrant (GDC-0810, ARN-810) is a potent ER-α binder (ER-α, IC50 = 6.1 nM; ER-β, IC50 = 8.8 nM), a full transcriptional antagonist with no agonism and displays good potency and efficacy in ER-α degradation (EC50 = 0.7 nM) and MCF-7 breast cancer cell viability (IC50 = 2.5 nM) assays with good selectivity over other nuclear hormone receptors.
In vitro DMSO 82 mg/mL (183.48 mM)
Water Insoluble
Ethanol 82 mg/mL (183.48 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.38 mL 111.88 mL 223.76 mL
0.5 mM 4.48 mL 22.38 mL 44.75 mL
1 mM 2.24 mL 11.19 mL 22.38 mL
5 mM 0.45 mL 2.24 mL 4.48 mL

*The above data is based on the productmolecular weight 446.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15958
Actions Degrader
CAS No. 1365888-06-7
Formula C26H20ClFN2O2
M. Wt 446.91
Purity >98%
Synonyms RG6046, ARN-810, ARN810, ARN 810
SMILES O=C(O)/C=C/C1=CC=C(C=C1)/C(C2=CC3=C(NN=C3)C=C2)=C(CC)\C4=CC=C(C=C4Cl)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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