Fig. 1 · Structure
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GDP-α-D-mannose disodium
GTP Inhibitor
GDP-α-D-mannose disodium serves as a GTP inhibitor, acting as a donor substrate for mannosyltransferases and a precursor for GDP-β-L-fucose. It exhibits competitive inhibition towards GTP, with a Ki value of 14.7 μM, and demonstrates uncompetitive inhibition with respect to mannose-1-phosphate, showing a Ki of 115 μM. This compound is valuable for investigations into glycosylation processes and the role of GTP in various cellular mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 148296-46-2 |
| Applications | GTP Inhibitor |
| Formula | C16H23N5Na2O16P2 |
| Molecular Weight | 649.30 |
| SMILES | O=P(OP(O[C@@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)(O[Na])=O)(O[Na])OC[C@@H](O2)[C@@H](O)[C@@H](O)[C@@H]2N3C(N=C(N)NC4=O)=C4N=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.