Fig. 1 · Structure
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GDP-D-mannose disodium
GTP Inhibitor
GDP-D-mannose disodium is a GTP inhibitor that serves as a crucial donor substrate for mannosyltransferases. Comprising GDP-α-D-mannose and GDP-β-D-mannose, this compound demonstrates competitive inhibition towards GTP with a Ki value of 14.7 μM, and an uncompetitive inhibition against mannose-1-phosphate with a Ki of 115 μM. It is employed in research applications aimed at elucidating glycosylation processes and studying glycan biosynthesis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 103301-73-1 |
| Applications | GTP Inhibitor |
| Formula | C16H23N5Na2O16P2 |
| Molecular Weight | 649.30 |
| SMILES | O=P(OP(OC1[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)(O[Na])=O)(O[Na])OC[C@@H](O2)[C@@H](O)[C@@H](O)[C@@H]2N3C(N=C(N)NC4=O)=C4N=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.