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GGFG-Exatecan TFA

Catalog No.: A98287
Drug Intermediate
GGFG-Exatecan TFA is a synthetic drug intermediate designed for use in antibody-drug conjugates (ADCs). This compound features a glycyl-glycyl-phenylalanyl-glycine (GGFG) tetrapeptide linker conjugated to Exatecan, a DNA topoisomerase I inhibitor. It plays a critical role in cancer research, facilitating the development of targeted therapeutic strategies.
GGFG-Exatecan TFA 223537-11-9 Drug Intermediate
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionGGFG-Exatecan TFA is a synthetic drug intermediate designed for use in antibody-drug conjugates (ADCs). This compound features a glycyl-glycyl-phenylalanyl-glycine (GGFG) tetrapeptide linker conjugated to Exatecan, a DNA topoisomerase I inhibitor. It plays a critical role in cancer research, facilitating the development of targeted therapeutic strategies.
Product Information
Catalog NumA98287
FormulaC41H41F4N7O10
Molecular Weight867.80
CAS Number223537-11-9
SMILESNCC(NCC(N[C@@H](CC1=CC=CC=C1)C(NCC(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O)=O)=O)=O.OC(C(F)(F)F)=O
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This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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