Fig. 1 · Structure
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Glp5,(Me)Phe8,Sar9 Substance P (5-11)
Substance P Analogue
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) is a Substance P analogue that selectively activates the neurokinin 1 receptor (NK1R) in the rat brain, exhibiting effects similar to those of Substance P with an extended duration of action. This compound plays a significant role in modulating dopamine metabolism within the mesencephalon and midbrain cortex. Additionally, [Glp5,(Me)Phe8,Sar9] Substance P (5-11) has been shown to enhance motor activity and facilitate recovery from addictive behavior in rodent models, making it a valuable tool in neuropharmacological research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 77128-69-9 |
| Applications | Substance P Analogue |
| Formula | C43H61N9O9S |
| Molecular Weight | 880.06 |
| Synonyms | DiMe-C7 |
| SMILES | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.