Fig. 1 · Structure
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Glucosylsphingosine
Glucocerebrosidase Inhibitor
Glucosylsphingosine is a specific non-competitive inhibitor of glucocerebrosidase, exhibiting a Ki value of 30 μM. This deacylated form of glucosylceramide demonstrates neurotoxic properties and is relevant for studies exploring the pathophysiology of lysosomal storage disorders, particularly Krabbe and Gaucher diseases. Its mechanism of action and biological activity make Glucosylsphingosine a valuable tool for researchers investigating therapeutic strategies for these conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 52050-17-6 |
| Applications | Glucocerebrosidase Inhibitor |
| Formula | C24H47NO7 |
| Molecular Weight | 461.63 |
| Synonyms | Glucopsychosine; Lyso-Gb1; Lyso-GL1 |
| SMILES | O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC[C@H](N)[C@H](O)/C=C/CCCCCCCCCCCCC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.