Fig. 1 · Structure
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Glutaminyl cyclases-IN-1
Glutaminyl Cyclases Inhibitor
Glutaminyl cyclases-IN-1 is a selective inhibitor of glutaminyl cyclases, exhibiting IC50 values of 12 nM for human QC and 73 nM for isoQC. This compound effectively disrupts the CD47/SIRPα interaction by inhibiting isoQC, thereby enhancing the phagocytic activity of THP-1 and U937 macrophages. Its potent mechanism makes it a valuable tool for research in immune modulation and myeloid cell activation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3032400-33-9 |
| Applications | Glutaminyl Cyclases Inhibitor |
| Formula | C25H30N6O2S |
| Molecular Weight | 478.61 |
| Synonyms | IsoQC-IN-1 |
| SMILES | COC1=C(C=CC(CN2C=NC3=CC(C4=NN=C(S4)N)=CC=C32)=C1)OCCCN5CCCCC5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.