GPX4-IN-18 is a ferrocene-containing inhibitor targeting glutathione peroxidase 4 (GPX4), recognized for its role in inducing ferroptosis. This compound significantly elevates reactive oxygen species (ROS) and malondialdehyde (MDA) levels in OS-RC-2 clear cell renal carcinoma cells, demonstrating potent biological activity. In HT-1080 cells, GPX4-IN-18 exhibits an IC50 of 0.007 μM in the absence of ferrostatin-1, and 1.486 μM when ferrostatin-1 is present. Additionally, GPX4-IN-18 has been shown to reduce tumor volume and intratumoral GPX4 levels in xenograft models, making it a valuable tool for researching ferroptosis-related pathways.
GPX4-IN-18 is a ferrocene-containing inhibitor targeting glutathione peroxidase 4 (GPX4), recognized for its role in inducing ferroptosis. This compound significantly elevates reactive oxygen species (ROS) and malondialdehyde (MDA) levels in OS-RC-2 clear cell renal carcinoma cells, demonstrating potent biological activity. In HT-1080 cells, GPX4-IN-18 exhibits an IC50 of 0.007 μM in the absence of ferrostatin-1, and 1.486 μM when ferrostatin-1 is present. Additionally, GPX4-IN-18 has been shown to reduce tumor volume and intratumoral GPX4 levels in xenograft models, making it a valuable tool for researching ferroptosis-related pathways.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
