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GR 82334

Catalog No.: A62058
Tachykinin NK1 Receptor Antagonist
GR 82334 is a potent and selective reversible antagonist of the tachykinin NK1 receptor. This compound effectively inhibits substance P-induced sensitization by blocking NK1 receptors, demonstrating its utility in research related to pain modulation and neurobiology. The specific mechanism of action makes GR 82334 a valuable tool for investigating the role of tachykinins in various biological processes and for exploring potential therapeutic applications.
GR 82334 129623-01-4 Tachykinin NK1 Receptor Antagonist
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1mg
$440.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionGR 82334 is a potent and selective reversible antagonist of the tachykinin NK1 receptor. This compound effectively inhibits substance P-induced sensitization by blocking NK1 receptors, demonstrating its utility in research related to pain modulation and neurobiology. The specific mechanism of action makes GR 82334 a valuable tool for investigating the role of tachykinins in various biological processes and for exploring potential therapeutic applications.
Product Information
Catalog NumA62058
FormulaC69H91N15O16
Molecular Weight1386.55
CAS Number129623-01-4
Sequence{Glp}-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-{d-Pro(spiro-γ-lactam)Leu}-Trp-NH2
Sequence shortening{Glp}-ADPNKFY-{d-Pro(spiro-γ-lactam)Leu}-W-NH2
SMILESC([C@H](CC1=CC=C(O)C=C1)NC([C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@@H](NC(=O)[C@H]3N(C([C@@H](NC([C@@H](NC(=O)[C@@H]4CCC(=O)N4)C)=O)CC(O)=O)=O)CCC3)CC(N)=O)=O)CCCCN)=O)=O)(=O)N5[C@@]6(C(=O)N([C@H](C(N[C@@H](CC=7C=8C(NC7)=CC=CC8)C(N)=O)=O)CC(C)C)CC6)CCC5
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GPCR/G Protein > Neurokinin Receptors