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GR 83074

NK-2 Antagonist

GR 83074 is a selective antagonist for the neurokinin 2 (NK-2) receptor, exhibiting a pKB of 8.23. It demonstrates significant potency with a 340-fold selectivity over the NK-1 receptor and is inactive as an NK-3 antagonist. This compound is valuable for research focused on the modulation of neurokinin pathways and their implications in various physiological and pathological conditions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	141636-44-4
Applications	NK-2 Antagonist
Formula	C₅₀H₇₂N₁₂O₉
Molecular Weight	985.18
SMILES	CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)OC(C)(C)C)C(N)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.