GR 83074

Name: GR 83074
Brand: Adooq Bioscience
SKU: A62049
Rating: 5 (288 reviews)

Catalog No.: A62049

NK-2 Antagonist

GR 83074 is a selective antagonist for the neurokinin 2 (NK-2) receptor, exhibiting a pKB of 8.23. It demonstrates significant potency with a 340-fold selectivity over the NK-1 receptor and is inactive as an NK-3 antagonist. This compound is valuable for research focused on the modulation of neurokinin pathways and their implications in various physiological and pathological conditions.

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Biological Activity

Description	GR 83074 is a selective antagonist for the neurokinin 2 (NK-2) receptor, exhibiting a pKB of 8.23. It demonstrates significant potency with a 340-fold selectivity over the NK-1 receptor and is inactive as an NK-3 antagonist. This compound is valuable for research focused on the modulation of neurokinin pathways and their implications in various physiological and pathological conditions.

Product Information

Catalog Num	A62049
Formula	C50H72N12O9
Molecular Weight	985.18
CAS Number	141636-44-4
Sequence	{Boc}-Arg-Ala-{D-Trp}-Phe-{D-Pro}-Pro-{Nle}-NH2
Sequence shortening	{Boc}-RA-{D-Trp}-F-{D-Pro}-P-{Nle}-NH2
SMILES	CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)OC(C)(C)C)C(N)=O

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