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GR 87389

Catalog No.: A62115
NK2 Receptor Antagonist
GR 87389 is a potent antagonist of the NK2 receptor, effectively inhibiting its activity. This compound has been shown to competitively block GA 64349-induced contractions in smooth muscle strips derived from human detrusor, prostate, and prostatic urethra tissues. GR 87389 is valuable in research applications focused on the role of NK2 receptors in smooth muscle physiology and potential therapeutic strategies for related disorders.
GR 87389 141663-86-7 NK2 Receptor Antagonist
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionGR 87389 is a potent antagonist of the NK2 receptor, effectively inhibiting its activity. This compound has been shown to competitively block GA 64349-induced contractions in smooth muscle strips derived from human detrusor, prostate, and prostatic urethra tissues. GR 87389 is valuable in research applications focused on the role of NK2 receptors in smooth muscle physiology and potential therapeutic strategies for related disorders.
Product Information
Catalog NumA62115
FormulaC47H65N9O9
Molecular Weight900.07
CAS Number141663-86-7
Sequence shortening{Boc}-AA-{D-Trp}-F-{D-Pro}-P-{Nle}-NH2
SMILESCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)OC(C)(C)C)C(N)=O
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GPCR/G Protein > Neurokinin Receptors