Fig. 1 · Structure
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GR 94800
NK2 Antagonist
GR 94800 is a potent and selective antagonist of the NK2 receptor, exhibiting a pKB value of 9.6, along with lower values of 6.4 and 6.0 for NK1 and NK3 receptors, respectively. This compound is valuable for investigating the role of NK2 receptors in various biological processes and can be employed in studies related to pain, inflammation, and neurogenic responses. Research applications include exploring neurokinin signaling pathways and potential therapeutic targets for related diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 141636-65-9 |
| Applications | NK2 Antagonist |
| Formula | C49H61N9O8 |
| Molecular Weight | 904.06 |
| SMILES | CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)c1ccccc1)C(N)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.