Fig. 1 · Structure
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GR127935 hydrochloride
5-HT1D/5-HT1B Receptor Antagonist
GR127935 hydrochloride is a potent antagonist of the 5-HT1D and 5-HT1B receptors, demonstrating pKis of 8.5 for both isoforms. It exhibits a significant 100-fold selectivity for the 5-HT1B and 5-HT1D receptors compared to other serotonin receptor subtypes, including 5-HT1A, 5-HT2A, and 5-HT2C. This compound is valuable for research involving neurological diseases and exploring serotonin receptor dynamics.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 148642-42-6 |
| Applications | 5-HT1D/5-HT1B Receptor Antagonist |
| Formula | C29H32ClN5O3 |
| Molecular Weight | 534.05 |
| SMILES | O=C(C1=CC=C(C2=CC=C(C3=NOC(C)=N3)C=C2C)C=C1)NC4=CC=C(OC)C(N5CCN(C)CC5)=C4.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.