Fig. 1 · Structure
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GR127935
5-HT1D/5-HT1B Receptor Antagonist
GR127935 is a selective antagonist for the 5-HT1D and 5-HT1B receptors, exhibiting a pKi of 8.5 for both isoforms. This compound demonstrates a significant 100-fold selectivity for the 5-HT1B and 5-HT1D receptors over 5-HT1A, 5-HT2A, and 5-HT2C receptors. GR127935 is primarily utilized in research focused on neurological disorders, aiding in the exploration of serotonergic signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 148672-13-3 |
| Applications | 5-HT1D/5-HT1B Receptor Antagonist |
| Formula | C29H31N5O3 |
| Molecular Weight | 497.59 |
| SMILES | O=C(NC1=CC=C(OC)C(N2CCN(C)CC2)=C1)C3=CC=C(C4=CC=C(C5=NOC(C)=N5)C=C4C)C=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.