Grazoprevir

Catalog No.: A17303

Hepatitis C virus NS3/4a protease inhibitor

Grazoprevir

Grazoprevir Chemical Structure

CAS NO. 1350514-68-9

Grazoprevir (MK-5172) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$155.00
50 mg
$460.00
100 mg
$920.00
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Biological Activity

Grazoprevir (MK-5172) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively.
In vitro DMSO 93 mg/mL (121.26 mM)
Water Insoluble
Ethanol 93 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.04 mL 65.2 mL 130.4 mL
0.5 mM 2.61 mL 13.04 mL 26.08 mL
1 mM 1.3 mL 6.52 mL 13.04 mL
5 mM 0.26 mL 1.3 mL 2.61 mL

*The above data is based on the productmolecular weight 766.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A17303
Actions Inhibitor
CAS No. 1350514-68-9
Formula C38H50N6O9S
M. Wt 766.9
Purity >98%
Synonyms MK-5172, MK5172, MK 5172
SMILES COC1=CC2=C(N=C(CCCCC[[email protected]@H]3C[[email protected]]3OC4=O)C(O[[email protected]]5CN(C([[email protected]](C(C)(C)C)N4)=O)[[email protected]](C(N[[email protected]@]([[email protected]@H]6C=C)(C6)C(NS(C7CC7)(=O)=O)=O)=O)C5)=N2)C=C1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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