Grazoprevir

Catalog No.: A17303
Hepatitis C virus NS3/4a protease inhibitor
Grazoprevir (MK-5172) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively.
Grouped product items
Product Name Price Stock Qty
Grazoprevir 5mg
$90.00
In stock
Grazoprevir 10mg
$155.00
In stock
Grazoprevir 50mg
$460.00
In stock
Grazoprevir 100mg
$920.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Biological Activity
Discription Grazoprevir (MK-5172) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively.
Product Information
Catalog Num A17303
Formula C38H50N6O9S
Molecular Weight 766.9
CAS Number 1350514-68-9
SMILES COC1=CC2=C(N=C(CCCCC[C@@H]3C[C@H]3OC4=O)C(O[C@H]5CN(C([C@H](C(C)(C)C)N4)=O)[C@H](C(N[C@@]([C@@H]6C=C)(C6)C(NS(C7CC7)(=O)=O)=O)=O)C5)=N2)C=C1
Synonyms MK-5172, MK5172, MK 5172
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 93 mg/mL (121.26 mM)
Water Insoluble
Ethanol 93 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.04 mL 65.2 mL 130.4 mL
0.5 mM 2.61 mL 13.04 mL 26.08 mL
1 mM 1.3 mL 6.52 mL 13.04 mL
5 mM 0.26 mL 1.3 mL 2.61 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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