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GS-443902

RdRp Inhibitor

GS-443902, an active triphosphate metabolite of Remdesivir, functions as a potent inhibitor of viral RNA-dependent RNA polymerases (RdRp). With IC50 values of 1.1 µM for respiratory syncytial virus (RSV) RdRp and 5 µM for hepatitis C virus (HCV) RdRp, it demonstrates significant antiviral activity. GS-443902 is valuable in research applications targeting RNA virus replication and is instrumental in studying antiviral agents and mechanisms.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1355149-45-9
Applications	RdRp Inhibitor
Formula	C₁₂H₁₆N₅O₁₃P₃
Molecular Weight	531.20
Synonyms	GS-441524 triphosphate; Remdesivir metabolite
SMILES	O=P(OP(O)(O)=O)(O)OP(OC[C@@H](O1)[C@@H](O)[C@@H](O)[C@]1(C#N)C2=CC=C3N2N=CN=C3N)(O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.