Fig. 1 · Structure
Documents & Downloads
GS-9191
Nucleotide Analog
GS-9191 is a prodrug of the nucleotide analog PMEG with a primary mechanism targeting nucleotide synthesis. It serves as a topical agent that effectively permeates the skin and is metabolized into the active nucleoside triphosphate analog within the epithelial layer. GS-9191 inhibits nucleic acid synthesis, leading to cell cycle arrest in the S phase and subsequent induction of apoptosis. This compound is valuable for research into human papillomavirus (HPV) infections.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 859209-84-0 |
| Applications | Nucleotide Analog |
| Formula | C37H51N8O6P |
| Molecular Weight | 734.82 |
| SMILES | CC(C)COC([C@H](CC1=CC=CC=C1)NP(COCCN2C3=NC(N)=NC(NC4CC4)=C3N=C2)(N[C@H](C(OCC(C)C)=O)CC5=CC=CC=C5)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.