Fig. 1 · Structure
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GSK-1482160 (isomer)
GSK-1482160 Isomer
GSK-1482160 isomer functions as a negative allosteric modulator of the P2X7 receptor (P2X7R), exhibiting oral bioavailability and the ability to penetrate the blood-brain barrier. With pIC50 values of 8.5 for human and 6.5 for rat, this compound effectively diminishes ATP's efficacy at P2X7R without altering its affinity, thus inhibiting the release of IL-1β. Additionally, GSK-1482160 serves as an excellent radioligand, available for labeling with isotopes such as 11C or 18F for imaging studies. Its applications extend to the investigation of chronic joint pain and the chronic constriction injury (CCI) model.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1695551-19-9 |
| Applications | GSK-1482160 Isomer |
| Formula | C14H14ClF3N2O2 |
| Molecular Weight | 334.72 |
| SMILES | ClC1=C(C(F)(F)F)C=CC=C1CN(C)C([C@@H]2CCC(N2)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.