GSK 2250665A

Catalog No.: A17191

Itk inhibitor

GSK 2250665A

GSK 2250665A Chemical Structure

CAS NO. 1246030-96-5

GSK-2250665A is a Itk inhibitor with pKi = 9.2, it Exhibits selectivity for Itk over Aurora B kinase and Btk (pIC50 values are 6.4 and 6.5, respectively) and a panel of other kinases. Inhibits IFNγ production in PBMCs.

Availability: In stock

Package Price Qty
5 mg
$100.00
10 mg
$180.00
50 mg
$540.00
100 mg
$920.00
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Biological Activity

GSK-2250665A is a Itk inhibitor with pKi = 9.2, it Exhibits selectivity for Itk over Aurora B kinase and Btk (pIC50 values are 6.4 and 6.5, respectively) and a panel of other kinases. Inhibits IFNγ production in PBMCs.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.76 mL 108.79 mL 217.58 mL
0.5 mM 4.35 mL 21.76 mL 43.52 mL
1 mM 2.18 mL 10.88 mL 21.76 mL
5 mM 0.44 mL 2.18 mL 4.35 mL

*The above data is based on the productmolecular weight 459.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A17191
Actions Inhibitor
CAS No. 1246030-96-5
Formula C26H29N5OS
M. Wt 459.61
Solubility DMSO
Purity >98%
Synonyms GSK2250665A, GSK-2250665A
SMILES CCC1=CC=C(N=C(NC3=NC(N[[email protected]]5CC[[email protected]](O)CC5)=NC(CC4=CC=CC=C4)=C3)S2)C2=C1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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