GSK-3484862 is a non-covalent and selective inhibitor of DNA methyltransferase 1 (DNMT1). It effectively induces DNA hypomethylation, making it a promising agent for cancer therapy. In murine embryonic stem cells, GSK-3484862 mediates robust and targeted demethylation with minimal off-target toxicity, supporting its potential for epigenetic reprogramming and therapeutic applications.
GSK-3484862 is a non-covalent and selective inhibitor of DNA methyltransferase 1 (DNMT1). It effectively induces DNA hypomethylation, making it a promising agent for cancer therapy. In murine embryonic stem cells, GSK-3484862 mediates robust and targeted demethylation with minimal off-target toxicity, supporting its potential for epigenetic reprogramming and therapeutic applications.
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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