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GSK-5503A

CRAC Blocker

GSK-5503A is a calcium-release activated calcium (CRAC) channel blocker that selectively inhibits stromal interaction molecule 1 (STIM1) mediated Orai1 and Orai3 currents in vitro. This compound demonstrates significant potential for elucidating the roles of CRAC channels in various physiological and pathological processes. GSK-5503A is applicable in research related to asthma and allergic disorders, offering insights into calcium signaling mechanisms involved in these conditions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Blocker
CAS Number	1253186-46-7
Applications	CRAC Blocker
Formula	C₂₃H₁₇F₂N₃O₂
Molecular Weight	405.40
SMILES	O=C(NC1=NN(CC2=CC=CC=C2OC3=CC=CC=C3)C=C1)C4=C(F)C=CC=C4F

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.