Fig. 1 · Structure
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GSK-J2 sodium
Inactive Isomer of GSK-J1
GSK-J2 sodium is the sodium form of GSK-J2, an inactive isomer of the active compound GSK-J1. While GSK-J1 functions as a potent inhibitor of the H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, GSK-J2 sodium does not exhibit specific biological activity. This reagent may be utilized in studies focused on differentiating between active and inactive isomers in the context of epigenetic regulation and demethylase inhibition.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2108665-15-0 |
| Applications | Inactive Isomer of GSK-J1 |
| Formula | C22H22N5NaO2 |
| Molecular Weight | 411.43 |
| SMILES | O=C(CCNC1=CC(N2CCC3=C(CC2)C=CC=C3)=NC(C4=CN=CC=C4)=N1)O[Na] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.