Fig. 1 · Structure
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GSK-J2
GSK J1 Inactive Isomer
GSK-J2 is an inactive isomer of the potent H3K27me3/me2-demethylase inhibitor GSK-J1, which targets JMJD3/KDM6B and UTX/KDM6A. While GSK-J1 effectively modulates histone methylation and can influence gene expression in various biological contexts, GSK-J2 serves as a control compound in research applications requiring differentiation between active and inactive forms. The specificity of GSK-J1 for its target enzymes facilitates the investigation of histone modification pathways and their implications in epigenetic regulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1394854-52-4 |
| Applications | GSK J1 Inactive Isomer |
| Formula | C22H23N5O2 |
| Molecular Weight | 389.45 |
| SMILES | O=C(O)CCNC1=NC(C2=CC=CN=C2)=NC(N3CCC(C=CC=C4)=C4CC3)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.